H2N2V1, Main, Exploration, bibRecord, 001F37

Sequence changes in the live attenuated, cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virus

Identifieur interne : 001F37 ( Main/Exploration ); précédent : 001F36; suivant : 001F38

Sequence changes in the live attenuated, cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virus

Auteurs : Alexander I. Klimov [Russie] ; Nancy J. Cox [États-Unis] ; Wagner V. Yotov [Russie] ; Elisabet Rocha [États-Unis] ; Galina I. Alexandrova [Russie] ; Alan P. Kendal [États-Unis]

Source :

Virology [ 0042-6822 ] ; 1992.

RBID : ISTEX:B240CD9FED52399ADC575CD9A10FDDA7FC3FDA3B

Descripteurs français

KwdFr :
- ADN viral, ARN viral (génétique), Basse température, Données de séquences moléculaires, Mutation, Protéines virales (génétique), Sous-type H2N2 du virus de la grippe A, Séquence d'acides aminés, Séquence nucléotidique, Vaccins antigrippaux (génétique), Vaccins atténués (génétique), Virus de la grippe A (génétique).
MESH :
- génétique : ARN viral, Protéines virales, Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
Pascal (Inist)
- ADN viral, Adaptation, Basse température, Données de séquences moléculaires, Froid, Grippe A, Influenzavirus A, Mutation, Souche atténuée, Sous-type H2N2 du virus de la grippe A, Substitution, Séquence d'acides aminés, Séquence nucléotidique.

English descriptors

KwdEn :
- Adaptation, Amino Acid Sequence, Attenuated strain, Base Sequence, Cold, Cold Temperature, DNA, Viral, Influenza A, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza Vaccines (genetics), Influenzavirus A, Molecular Sequence Data, Mutation, RNA, Viral (genetics), Substitution, Vaccines, Attenuated (genetics), Viral Proteins (genetics).
MESH :
- chemical , genetics : Influenza Vaccines, RNA, Viral, Vaccines, Attenuated, Viral Proteins.
- chemical : DNA, Viral.
- genetics : Influenza A virus.
- Amino Acid Sequence, Base Sequence, Cold Temperature, Influenza A Virus, H2N2 Subtype, Molecular Sequence Data, Mutation.
Teeft :
- Attenuated, Attenuation, Avian, Cellular biology, Donor strains, Ghendon, Human influenza viruses, Influenza, Influenza virus strains, Kendal, Klimov, Leucine, Maassab, Medical sciences, Multiple mutations, Mutant, Mutation, Nucleotide, Nucleotide differences, Possible candidates, Primer, Proline substitution, Reassortant, Reassortant vaccines, Research institute, Segments coding, Sequence changes, Sequence data, Sequencing, Single mutation, Soviet union, Substitution, Ucla symposia, Universal primer, Vaccine, Vaccine strains, Valine substitution, Viral, Virology.

Abstract

Abstract: Nucleotide sequences were determined for the RNA segments coding for proteins other than the hemagglutinin and neuraminidase of the A/Leningrad/134/57 (H2N2) wild-type (A/Len/wt) virus and its two cold-adapted (ca) and attenuated variants, A/Leningrad/134/17/57 (A/Len/ 17/ca) and A/Leningrad/134/47/57 (A/Len/47/ca) that are used in the U.S.S.R. in the preparation of reassortant live attenuated vaccines. Ten nucleotide differences were detected between the sequences of the A/Len/wt and A/Len/17/ca viruses; of these, eight were deduced to encode amino acid (aa) substitutions. One as substitution each was predicted for the PB2, M1, M2, and NS2 proteins, whereas two as substitutions each were predicted for the PB1, and PA proteins of the A/Len/17/ca virus. Four additional nucleotide changes were found in the genome of the A/Len/47/ca virus; three of these were deduced to code for one additional as substitution each for the PB2, PB1, and NP proteins.

Url:

https://api.istex.fr/ark:/67375/6H6-C6C7TDT5-R/fulltext.pdf

DOI: 10.1016/0042-6822(92)90050-Y

Affiliations:

Le document en format XML

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<term>Amino Acid Sequence</term>
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<term>Base Sequence</term>
<term>Cold</term>
<term>Cold Temperature</term>
<term>DNA, Viral</term>
<term>Influenza A</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza Vaccines (genetics)</term>
<term>Influenzavirus A</term>
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<term>Vaccines, Attenuated (genetics)</term>
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<term>Données de séquences moléculaires</term>
<term>Mutation</term>
<term>Protéines virales (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins atténués (génétique)</term>
<term>Virus de la grippe A (génétique)</term>
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<term>RNA, Viral</term>
<term>Vaccines, Attenuated</term>
<term>Viral Proteins</term>
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<term>Protéines virales</term>
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<term>Vaccins atténués</term>
<term>Virus de la grippe A</term>
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<term>Base Sequence</term>
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<term>Influenza A Virus, H2N2 Subtype</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
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<front><div type="abstract" xml:lang="en">Abstract: Nucleotide sequences were determined for the RNA segments coding for proteins other than the hemagglutinin and neuraminidase of the A/Leningrad/134/57 (H2N2) wild-type (A/Len/wt) virus and its two cold-adapted (ca) and attenuated variants, A/Leningrad/134/17/57 (A/Len/ 17/ca) and A/Leningrad/134/47/57 (A/Len/47/ca) that are used in the U.S.S.R. in the preparation of reassortant live attenuated vaccines. Ten nucleotide differences were detected between the sequences of the A/Len/wt and A/Len/17/ca viruses; of these, eight were deduced to encode amino acid (aa) substitutions. One as substitution each was predicted for the PB2, M1, M2, and NS2 proteins, whereas two as substitutions each were predicted for the PB1, and PA proteins of the A/Len/17/ca virus. Four additional nucleotide changes were found in the genome of the A/Len/47/ca virus; three of these were deduced to code for one additional as substitution each for the PB2, PB1, and NP proteins.</div>
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Serveur d'exploration H2N2

Sequence changes in the live attenuated, cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virus

Sequence changes in the live attenuated, cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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